![]() ![]() This recognition was not observed for Capto Adhere. Capto Q ImpRes provided a recognition for guanylate bases when samples of deoxynucleotides or poly(dG) were examined. All deoxynucleotides and DNAs tested bound strongly to the chromatographic materials and could be eluted by a linear gradient of increasing NaCl concentration. These variations in biophysical properties have been utilized for comparative separations on these two resins. The intrinsic differences between single- and double-stranded DNAs are related to charge, hydrophobicity, size and three-dimensional structure. Capto Adhere carries a multimodal ligand which combines strong anion with aromatic recognition, while Capto Q ImpRes is a strong anion exchanger with a chemically similar ligand, but without a phenyl group. In addition, the potential for pre-packed columns to be gamma sterilized provides a compelling value proposition for companies looking to implement multi-column chromatography.The differences in chromatographic behaviour of individual deoxynucleotides as well as small single-stranded and double-stranded DNA molecules have been examined for two resins from the Capto family: Capto Adhere and Capto Q ImpRes. Banks of multiple pre-packed columns can be delivered ready to run eliminating the need for multiple self-packed columns. This transfer of operational risk helps adopters of pre-packed columns to maintain leaner operations and focus on the most critical aspects of making and purifying therapeutic proteins.Īs the industry evolves to incorporate continuous processing, pre-packed columns are a perfect fit for multi-column chromatography. This allows a bioprocessing facility to outsource column packing, a non-value added step for making therapeutic proteins, and no longer worry about column packing issues. The ability of pre-packed column suppliers to focus their operations on column packing results in more consistently packed columns over time. Replacing traditional self-packed glass or stainless steel columns, pre-packed columns are packed by experts in state of the art facilities and are delivered ready to use for GMP processing. Operational flexibility for multi-product facilities.Rapid change over (no column packing, unpacking, or cleaning validation).In particular, adopters of pre-packed columns have realized the following benefits: Use of pre-packed columns in downstream chromatography has increased in response to the needs of multi-product facilities and initiatives focused on reducing change over time. SpectraPor Tube-A-Lyzer Dialysis Device.SpectraPor Micro Float-A-Lyzer® Ready-to-use Dialysis Device.SpectraPor Standard Grade Regenerated Cellulose (RC) Customized Dialysis Membranes.SpectraPor Pre-treated Standard Grade RC Dialysis Tubing and Trial Kits.SpectraPor Biotech Grade Regenerated Cellulose (RC) Dialysis Membrane.SpectraPor Biotech Grade Cellulose Ester (CE) Dialysis Membrane.SpectraPor 1-5 Dry Standard Grade Regenerated Cellulose (RC) Dialysis Tubing & Trial Kits.SpectraPor 1-4 Standard Grade Regenerated Cellulose (RC) Single-Layer Dialysis Membrane.SpectraPor Pre-wetted Standard Grade RC Dialysis Tubing and Trial Kits.SpectrPor Dialysis Tubing and Membranes Overview ![]() SpectrPor Dialysis Tubing and Membranes. ![]()
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